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The New Testament is silent regarding St. Paul's subsequent activities. The Pastoral Epistles suggest that St. Paul was released from prison and made another journey to Asia around the year 63. His companions were Timothy and Titus, the latter whom he left at Crete (Titus 1:5).
On his way to Macedonia St. Paul stopped in Ephesus, where he left Timothy to stop the spread of false teaching in the church (1 Tim. 1:3). On his return to Ephesus St. Paul was arrested again, probably at Troas (2 Tim. 4:13). Under Roman custody St. Paul apparently stopped at Miletos, leaving Trophimus sick there (2 Tim. 4:20).
With St. Paul again in chains at Rome, contact with him proved highly risky. Everyone from Asia deserted him except for one man from Ephesus named One siphorus, who searched for St. Paul and refreshed him (2 Tim. 1:15-18). Tradition places St. Paul's death in Rome during Nero's persecution of Christians around 65.
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